A young woman goes in search of her father, a professional gambler who abandoned her years before. Along the way, she finds herself at odds with her boyfriend who wants nothing but a carefree lifestyle.

Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

In Las Vegas, two best friends--a casino executive and a Mafia enforcer--compete for a gambling empire and a fast-living, fast-loving socialite.