In a quiet suburban neighborhood, two sisters are about to experience the dark and sinister world of Terror Toons.

Set during the Cold War, the Soviets—led by sword-wielding Irina Spalko—are in search of a crystal skull which has supernatural powers related to a mystical Lost City of Gold. Indy is coerced to head to Peru at the behest of a young man whose friend—and Indy's colleague—Professor Oxley has been captured for his knowledge of the skull's whereabouts.

Hilarity ensues when an uptight entrepreneur butts heads with his stoner brother as they battle to save their fledgling medical marijuana dispensary!