After years of rotting in Joliet, Les, a wrongfully imprisoned street legend known as "The Ghoul", is released into a mad search through Chicago's back alleys for the man who slaughtered his mother and robbed him of his soul. Aided by mysterious benefactors, he must delve beneath the city into a modern labyrinth of gutters whose tendrils have grown deep while he was gone. What unfolds is a desperate tale of brute force tragedy set in the supernatural underworld of Chicago, where heroes are reduced to horror-shows, villains dream of their own demise, and good and evil prove to be antiquated concepts.

Coming out of an accident with amnesia, Sophie Bauer tries to reshape herself in the eyes of those who knew her best.