Dr. Frankenstein and his monster both turn out to be alive after being attacked by an angry mob. The now-chastened scientist attempts to escape his past, but a former mentor forces him to assist with the creation of a new creature.

In 1920s Chicago, Italian immigrant and notorious thug, Antonio 'Tony' Camonte, aka Scarface, shoots his way to the top of the mobs while trying to protect his sister from the criminal life.

As American policemen in London, Bud and Lou meet up with Dr. Jekyll and Mr. Hyde.

Henry Frankenstein pieces together body parts in the hope of bringing a human-like creature to life. The mad scientist’s dreams are shattered by his monstrous creation awakening with rage to a world that hates and fears him.

One of the sons of late Dr. Henry Frankenstein finds his father's ghoulish creation in a coma and revives him, only to find out the monster is controlled by Ygor who is bent on revenge.

Deranged scientist, Gustav Niemann, escapes from prison and overtakes the director of a traveling chamber of horrors, soon reviving the infamous Count Dracula, the frozen Frankenstein Monster, and the Wolf Man.

The baron's grandson rents the family castle to a TV crew to fund his atomic revival of the family monster.

The villainous Dr. Fu Manchu races against a team of Englishmen to find the tomb of Ghengis Khan, because he wants to use the relics to cause an uprising in the East to wipe out the white race.

Clips from assorted television programs, B-movies, commercials, music performances, newsreels, bloopers, satirical short films and promotional and government films of the 1950s and 1960s are intercut together to tell a single story of various creatures and societal ills attacking American cities.

We have writer Fadiman, regulars Franklin P. Adams, Oscar Levant, and John Kieran, with Boris Karloff as the guest panelist for this edition of Information Please.