John Arnold DeMarco is a man who believes he is Don Juan, the greatest lover in the world. Clad in a cape and mask, DeMarco undergoes psychiatric treatment with Dr. Jack Mickler to cure him of his apparent delusion. But the psychiatric sessions have an unexpected effect on the psychiatric staff and, most profoundly, Dr Mickler, who rekindles the romance in his complacent marriage.

Reuben Feffer is a guy who's spent his entire life playing it safe. Polly Prince is irresistible as a free-spirit who lives for the thrill of the moment. When these two comically mismatched souls collide, Reuben's world is turned upside down, as he makes an uproarious attempt to change his life from middle-of-the-road to totally-out-there.

Eddie is a con artist. When he's framed and comes before a judge, he hopes to get off the hook by claiming insanity—but instead ends up in a hospital for a mental assessment. That night, a storm causes a power failure and, in the ensuing chaos, Eddie is mistaken for a doctor and suddenly finds himself in charge of the hospital.

Eugene, a young teenage Jewish boy, recalls his memoirs of his time as an adolescent youth. He lives with his parents, his aunt, two cousins, and his brother, Stanley, whom he looks up to and admires. He goes through the hardships of puberty, sexual fantasy, and living the life of a poor boy in a crowded house.

Judy Berlin is an aspiring actress whose idealism is at odds with her small suburban community, where a solar eclipse induces town inhabitants (a lonely housewife, a frustrated schoolteacher, and a struggling filmmaker) to search for solace and understanding in themselves and one another.

When a couple breaks up after four years together, the man is told that the son he has raised as his own isn't his biological one. He must fight to keep him.

A nuclear-powered bus is making its maiden non-stop trip from New York to Denver. The journey is plagued by disasters due to the machinations of a mysterious group allied with the oil lobby. Will the down-on-his-luck driver, with a reputation for eating his passengers, be able to complete the journey?

Jeff and Mari Thompson are contently married, but they are stunned to see many of their friends and neighbors going through separations and divorces. Seemingly surrounded by people with domestic problems, Jeff and Mari begin to question their own relationship.

Oliver is in trouble. He's been caught embezzling money from his father's company, and unless he can pay back the $250,000 he took (which he can't), he will be fired from his job, arrested and probably sent to jail. Meanwhile, his rich wife has not only refused to bail him out of this mess, she's planning to divorce him. Desperate, Oliver thinks up a way out. He takes out an insurance policy on his wife with him as the beneficiary, then hires a hit man to kill her. The only problem is that because the doctor who performed the examination is an incompetent fraud, the insurance policy is invalid. Desperate to call off the hit, Oliver tracks down the hit man, only to find that he's subcontracted the killing to another hit man. Tracking down that killer reveals that he, too, has hired it out to a third person, and so on, and so on. Just how many people are trying to kill Oliver's wife?

When the First Daughter is kidnapped by an African tribe, the President must do what he can to keep them from sacrificing her.