When the Justice League goes missing and villains overrun Metropolis, there's only one team that can solve this mystery: Scooby-Doo and the gang! But wait, there's a new dog in town – Krypto – Superman's Superdog with Super Powers. Mystery Inc. will need all the help it can get when phantoms menace the Justice League's headquarters.

Death is coming. Worse than death: oblivion. Not just for our Earth, but for everyone, everywhere, in every universe! Against this ultimate destruction, the mysterious Monitor has gathered the greatest team of Super Heroes ever assembled. But what can the combined might of Superman, Wonder Woman, Batman, The Flash, Green Lantern and hundreds of Super Heroes from multiple Earths even do to save all of reality from an unstoppable antimatter armageddon?!

When Batman goes missing, it takes the entire Bat "family" - including Batwoman and Batwing - to keep the peace in Gotham and unravel the mystery behind the Dark Knight's disappearance.