Fabio Leone and Paolo Pecora are two police officers from Rome, who, together with the careless Neapolitan Ciro Marmotta, are fired from the barracks due their scuppering of a plan to capture a secret agent.

In many small episodes, various characters represent the typical vices and comedy of Italian society in early 2000.

Roberto is a doctor in a small town near Naples. He suffers from a severe heart disease and he is heading toward an American hospital for a dangerous surgery with little or no hope of surviving. Therefore he talks to his best friend since childhood, Michele, a columnist at the local newspaper, explaining his last and long-wanted desire: having sex once with his Swedish beautiful wife, Frida.

A police inspector has to help an eccentric stranger who seems to have lost his memory.

The famous Italian football coach Oronzo Canà has retired to a villa in Apulia. Now, old and tired, he is enjoying a quiet life there, cultivating his vineyard, when suddenly he is summoned to Milan, in northern Italy. There the elderly chairman of a great Lombard ("Longobarda") club is suffering from dementia and has lost his powers of judgement, and the club's manager has been fired. He has decided to bring back Oronzo Canà as trainer, remembering him from his great football team of thirty years before, tasking him with bringing the club back to its old winning ways. Oronzo puts his trust in the intervention of a Russian billionaire who has bought the club for promotion. But it is a deception.

Several groups of Italians experience amusing adventures and tests of character on the Caribbean island of Antigua. Some of the characters are there simply for rest and relaxation, while others act with different motivations. Multiple plot lines unfold simultaneously as different characters' stories are presented.