After dominating the boxing world, Adonis Creed has thrived in his career and family life. When a childhood friend and former boxing prodigy, Damian Anderson, resurfaces after serving a long sentence in prison, he is eager to prove that he deserves his shot in the ring. The face-off between former friends is more than just a fight. To settle the score, Adonis must put his future on the line to battle Damian — a fighter with nothing to lose.

In a world in which the past, present and future simultaneously unfold, a woman whose genetic mutation leaves her devoid of morality struggles to preserve her romance with the man she loves.

Three mysterious figures emerge from the Mojave Desert and make their way to Los Angeles, leaving a trail of bodies in their path.