A widowed trucker fends off isolation in the company of a dog named Girl, two bickering sisters try to reconcile their differences and a down-and-out circus clown and his stripper girlfriend must fight the temptation of crime on the road. Their common companion is an angry disc jockey at odds with a desperate boss. All these people will find their lives intertwined by the hand of fate. And before the night gives way to day, some will breathe their last breath... Outside Ozona.

A young man is in a race against time as he searches for a cure after becoming infected with a virus that will eventually turn him into a blood-sucking vampire.

After a woman discovers her husband cheating on her, she decides to go on a road trip with her husband's mistress. While driving the two women pick up a hitchhiker, who may be on the run from the cops. With the police on their tail, the women inadvertently fall in with the criminal.