Uptight and straight-laced, FBI Special Agent Sarah Ashburn is a methodical investigator with a reputation for excellence--and hyper-arrogance. Shannon Mullins, one of Boston P.D.'s "finest," is foul-mouthed and has a very short fuse, and uses her gut instinct and street smarts to catch the most elusive criminals. Neither has ever had a partner, or a friend for that matter. When these two wildly incompatible law officers join forces to bring down a ruthless drug lord, they become the last thing anyone expected: buddies.

Hasn't every woman ever wondered whether it's best to ditch all the men and just marry your best friend? Paula and Emily are doing just that. Single hotel owner Paula Atkinson and her impulsive friend Emily van Garden have known each other since high school and have always been able to rely on each other. In a love crisis, Emily therefore moves into the "Seaside Hotel" and supports Paula. When Emily catches her fiancé Frank with someone else a few days before the wedding and Paula realizes after an upsetting visit to the doctor that no one will be there for her nine-year-old daughter Lucy in an emergency, the two spontaneously order the posse in a two-girlfriends-against-the-rest-of-the-world moment.