India. The spoilt and stubborn Edwina Esketh, comes to a small town with her husband. She falls in love with an indian doctor, Dr. Safti. She also meets an old friend of hers, the alcoholic Tom Ransome. An awful earthquake is followed by days of rain.

Venetian merchant Marco Polo travels to the East and the court of Kublai Khan who makes him an emissary and sends him on diplomatic missions throughout his empire. Over many years, Polo learns new cultures and languages, but he is haunted by the face of a mysterious woman whom he had met before leaving Venice and encounters her face in every woman he sees. Eventually returning to Venice to share his exotic and esoteric knowledge, Marco Polo once again finds the woman of his dreams. The Adventures of Marco Polo was an original, live television musical which was broadcast on NBC on April 14, 1956.