Kay and Jay reunite to provide our best, last and only line of defense against a sinister seductress who levels the toughest challenge yet to the MIB's untarnished mission statement – protecting Earth from the scum of the universe. It's been four years since the alien-seeking agents averted an intergalactic disaster of epic proportions. Now it's a race against the clock as Jay must convince Kay – who not only has absolutely no memory of his time spent with the MIB, but is also the only living person left with the expertise to save the galaxy – to reunite with the MIB before the earth submits to ultimate destruction.

Firefighters Chuck Ford and Larry Valentine are guy's guys, loyal to the core—which is why when widower Larry asks Chuck to pose as his lover so that he can get domestic partner benefits for his kids, his buddy agrees. However, things get dicey when a bureaucrat comes calling, and the boys are forced to present a picture of domestic bliss.

After bowler Roy Munson swindles the wrong crowd and is left with a hook for a hand, he settles into impoverished obscurity. That is, until he uncovers the next big thing: an Amish kid named Ishmael. So, the corrupt and the hopelessly naive hit the circuit intent on settling an old score with Big Ern.