In a story that follows some lives and their respective reincarnations over time, Valerio is a prince in the year one thousand and a doctor of the S.e.r.t. in the year two thousand. Altea on the other hand is a princess, who after a thousand years was reincarnated as a university student who volunteers as a mission and it also operates in the same S.e.r.t.. Their antagonist, in the past as in the present, is a man who was an alchemist and who today is the evil director of the same hospital where the S.e.r.t. is located. of Valerio and Altea. A rather anomalous director, given that he takes advantage of the cover offered by his position to traffic drugs in a big way. A fourth character is added to the three, Herrmugnen, who in the story embodies the mythological figure of the giant hero.

Barbara and Matteo are two Italians who live in Miami, managing a small restaurant overlooking the sea. Barbara is pregnant and the happy event brings their respective parents together in Miami: Massimo, Matteo's father, who has recently become a widower and has a hotel in Cortina, and Angela, Barbara's mother, who instead has a chain of restaurants and is separated from her husband. At first, the incompatibility between the two is sky-high. Then, while events, misunderstandings and plots of various kinds revolve around them, the ice slowly begins to break and affinities emerge when the two find themselves busy restoring peace between their children, who have entered into a crisis due to the birth of the little girl.

Maximus's life has officially come to a standstill, on the brink of a precipice. However, he is magically transported to ancient Rome. There, using his connections, Maximus saves Julius Caesar's life, foiling the assassination attempt that would have killed him and becoming his most trusted advisor.