Peter Quill, still reeling from the loss of Gamora, must rally his team around him to defend the universe along with protecting one of their own. A mission that, if not completed successfully, could quite possibly lead to the end of the Guardians as we know them.

Inside of his book, adventurous Harold can make anything come to life simply by drawing it. After he grows up and draws himself off the book's pages and into the physical world, Harold finds he has a lot to learn about real life.

Four friends' lives become intertwined when romance blooms between a doctor and a comedian, while his best friend falls for her free-spirited bestie. After a tragic event, their relationships evolve into something deeper than friendship.