Virus hysteria tells the story of a film crew filming a zombie-themed work at a mountain resort. Here, the whole crew had a real zombie accident, not a movie image anymore. The main source is due to the toxic, unknown foods widely sold in the market that have poisoned people. The zombie crew struggled to survive and made their way to the airport to seek help from the government and military.

Trang, a real estate agent who was raped, fears her boyfriend Hiệp will leave her, so she lures him to a homestay to propose. There, she is horrified to meet Long—the owner—who looks exactly like her attacker. Adding to the mystery, Long’s wife, Ngọc, also turns out to be one of the man’s victims. As Trang secretly investigates the truth, the situation grows increasingly tangled, revealing a dark conspiracy awaiting them all.