ER doctor Tsuyoshi Matsuoka receives a patient with a virus unlike anything he's seen before. His symptoms include high fever, convulsions, vomiting of blood and multiple organ failure. Could this be a new form of influenza or is it some other variety of virus? As the situation worsens and more cases begin arriving, a medical officer from the World Health Organization named Eiko Kobayashi is dispatched to the area. At the rate the virus is spreading, the entire city’s transportation system and infrastructure would be brought to a halt within 3 months. Within 6 months it could spread to tens of millions of people--reaching a death toll far worse than any war.

The story of a teenage boy called Yu, who falls for Yoko, a girl he runs into while working as an upskirt photographer in an offshoot of the porn industry. His attempts to woo her are complicated by a spot of cross-dressing – which convinces Yoko that she is lesbian – dalliances with kung-fu and crime, and a constant struggle with Catholic guilt.

The movie's title is a play on the popular Always - Sunset on Third Street films and also deals with circumstances 1950's Tokyo, but focuses on the homosexual district of Shinjuku ni-chome.

Daigo, a cellist, is laid off from his orchestra and moves with his wife back to his small hometown where the living is cheaper. Thinking he’s applying for a job at a travel agency he finds he’s being interviewed for work with departures of a more permanent nature – as an undertaker’s assistant.