On the run, Marian returns to her hometown in upstate New York to hide out with her estranged identical twin sister, Vivian. Struggling to put the past behind her, Marian lies about the reason for her return, leaving her sister in the dark until their two worlds begin to collide.

When Detective Sarah takes in her troubled teenage niece Emily, she discovers a dark family secret: Emily carries the curse of the Blue Moon. As the full moon rises, Sarah is forced into a dangerous world of bloodlines, betrayals, and supernatural forces that threaten to tear them apart. Howl of the Blue Moon is a haunting supernatural crime drama that explores loyalty, sacrifice, and the thin line between humanity and the monster within.