Based on the tale by Dale Jarvis, "Lady at Number 16" tells the story of two sailors in the 1800s that help a young lady back into her mansion. They return a few hours later to realize that their night was not all that it had seemed, and it may have had a more sinister twist than expected.

With their relationship on the rocks, David and Emily move to Halifax to catch a break from the pandemic and their monotonous routine. Upon meeting Emily's best friend Delilah and her local friend Meg, the already shaky groundwork of their relationship starts to fracture.

While dealing with the aftermath of escaping an abusive relationship, Heather starts to believe there is a vampiric shape shifting creature trying to trick her into getting inside her home. Memories of witnessing a traumatic event years ago involving the same creature come flooding back after she is mysteriously gifted the creatures calling card - a smooth stone engraved with a strange symbol. With the help of a supportive friend, Heather must finally confront her demons in the form of the monster that is haunting her, and summon her inner strength to finally defeat it.

Roommates Lorenzo, Calvin, Lee, and Adam go about their daily lives while trying to cope with a joint loss.