Karma tells the story of a group of three childhood friends: Koffi, Chris, and Ahmess. While building his career as a rapper, Ahmess decides, on the advice of his two companions, to stop his illegal activities. But unfortunately, the streets and certain past events catch up with them...

When Ross is diagnosed with terminal brain cancer and given six weeks to live, his newly engaged older brother Seth offers to spend his $50,000 wedding fund on a final trip of a lifetime. Their plans are complicated when Ross invites a call girl to join the group and Seth’s uptight fiancée insists on tagging along. This raucous road trip comedy features hip-hop star Asher Roth.