Twenty years have passed since those two apartments in the heart of Mexico City were the battlefield of a war of the sexes between Ana, Carlos, Andrea, Miguel, Tomás and María. All that is left of those apartments are memories and the image of Tomás' dead body at the bottom of the elevator shaft. Their lives have changed, their families have grown and new and unexpected characters have come to unsettle their daily lives and trigger a chain of events that will make them realize that modesty has been replaced by public disclosure; sex is only an app away; but love...love is still something elusive that everyone in today's banal and chaotic world is seeking.

"My best gift" is the story of Daniel (Plutarco Haza), who is facing difficult times both affective and professionally, but life gives him a motivation to keep going. One day, Don Gustavo (Aaron Hernan) unexpectedly knocks at his door, arriving with the news that he has a daughter, Samantha (Sophia de la Mora), the product of a relationship with an ex girlfriend (Eréndira Ibarra) 8 years ago; but unfortunately she died and now he has to take care of his daughter.

Sebastian is very lucky with women, going to parties and getting drunk every night. His mother asks him to change his way of life but he refuses to stop partying and meeting new women. One day, after one night of serious partying he wakes up with a beautiful woman named Alexa. He realizes he got married to her, but he can't remember anything about it. And being married is a serious problem for a man like him.

A successful and somewhat vain lawyer loses her mobile phone and is contacted by a stranger who wants to give it back. Charming and interesting, their instant connection blossoms but everything changes when they meet and she discovers a tiny little detail about him: he's rather short.

The daughter of a rich business man gets involved with New Age beliefs that clash with Christianity.