Guddu Ki Gun is the tale of Govardhan aka Guddu (Kunal Kemmu), a Bihari settled in Kolkata. He is a door-to-door washing powder salesman, whose sales pitch is "Ek washing powder ke saath Guddu free". While sharing a room with his close friend Ladoo (Sumeet Vyas), Guddu leads an amorous lifestyle in Kolkata. His travails begins when he ditches one of his girlfriends, Bholi (Aparna Sharma). Furious for forsaking his granddaughter, Bholi's grandfather casts a black magic spell on him. The only way Guddu can get rid of the curse is to find true love and by staying faithful to her.

An elderly Punjab man is saddened to find his wealthy son and grandchildren have abandoned their traditional Indian culture and morals while living in Australia.

On the bustling streets of Mumbai, Rani and Jaydeep, reunited after ten years, rekindle their bittersweet school romance. Their love faces a major challenge as Jaydeep battles a life-threatening health crisis, pushing Rani into a desperate search for a kidney transplant. Amid uncertainty and emotional turmoil, their bond deepens and inspires hope and resilience. Their courage and love prove that miracles can happen even in the face of the impossible.