This offbeat dark comedy take place when four friends have a backyard bar-b-q and decide to come up on some bud. Not knowing where to turn, because the streets have been dry for a few months, they end up scoring from the son of a over protective mob figure by the name of Fredrico, who vows, if anything should happen to his son, their will be hell to pay. After a tragic accident, the four friends are on the run with only one person to turn to, Krego, Brisco's long time friend. Krego confirms to them, Fredrico is a very powerful man, and there is no escaping his fury. Their only option is to change their appearance through underground plastic surgery, which would take them on a five hundred mile road trip. Along the way, they will have to avoid Fredrico's beautiful assassin, Venus, and other unsavory characters, leaving them to ponder the question, was it just dumb luck, or was it the bud?

A seasoned professional killer is finally offered the big cash score that has always eluded him, but there's a catch. He and five other rival criminals must work together to complete a series of jobs dictated by a mysterious and anonymous employer. It quickly leads to numerous set-ups, double crosses and wild car chases.