Nordvest is a gangsterfilm set in the suburbs of Copenhagen. Casper (18), the oldest of 3 siblings, survives life on the streets by committing burglaries for the neighbourhood boss, Jamal. When Casper gets an offer to work for Jamal’s rival Björn, he jumps at the chance for a better life, making his way into a world of drugs and prostitution. As things escalate between Björn and Jamal, Casper finds himself and his family dead center of a conflict, that threatens to destroy them.

Life becomes troublesome when 10-year-old Kalle's newborn sister has a birth defect on her back resembling wings. Only he sees the true miracle of his sister's odd appendages. When she is sent to the renowned Plastic Palace Clinic of cosmetic surgery for an amputation, Kalle sets out on a rescue mission. On the road, he meets Alf, a reclusive mechanic, who agrees to help. Together, they take off in Alf's vintage Cadillac in a race against time through an autumn-colored world of song and dance.