According to an ancient legend of the Sicilian tradition, the Natives are a lineage of fascinating women endowed with extraordinary powers, whose spirits manage to separate from their bodies to torment and ruin the lives of the unfortunate victims of the moment. The one who feels persecuted by a Native is Michela, a young doctor who, after returning to her small hometown on the slopes of Etna, witnesses a progressive derailment of her professional and emotional life. Paranoid and suspicious of everyone, Michela needs to identify who her enemy is among the many women around her and face her head on before it's too late.

Palermo, Sicily, 1980. Mafia member Tommaso Buscetta decides to move to Brazil with his family fleeing the constant war between the different clans of the criminal organization. But when, after living several misfortunes, he is forced to return to Italy, he makes a bold decision that will change his life and the destiny of Cosa Nostra forever.

Catania, 1960s. At the beach resort run by the charming Rozzo Finocchiaro, Stefano, a blind elderly man, observes and comments with ironic and acerbic commentary on the behavior of the people who frequent the beach and whose lives are intertwined. Passing under his scrutiny are the industrialist Alfredo Condorelli—married to the wealthy Maria Rita and engaged in a clandestine affair with his secretary Rosalba—the stifling Rosa—wife of the former playboy Alfredo—the four bigwigs Roberto, Michele, Armando, and Rocco; the musician Gregorio Alacci; the fallen boss Jano Suarez; the Lanzafame family; and Peppino Di Paternò—a fifty-year-old married to the statuesque Ulla.