Asuka is an aspiring model who moves to Tokyo to pursue her career. She moves into a small apartment with a friend of a friend, Kasumi. A bizarre murder occurs in the hotel across the street. The body was mutilated and repositioned into a lurid work of art. After this, a string of murders start happening all around the two girls, as if some crazed serial killer was following them. At the scene of each crime, the perpetrator leaves a black lip print, and is subsequently dubbed "The Black Kiss."

Based on the life of pioneering manga artist Shinichi Abe, "Miyoko asagaya kibun" starts from the 1970's in Asagaya District of Tokyo where Shinichi Abe began his career with then model girlfriend Miyoko.

In a future where World War II never ended, Japan is decimated by nightly bombings. The only building left standing is known as the Media Station, a broadcasting center responsible for all of Japan's entertainment.