The film depicts a dystopian world very close to our own. Every November, people go into hibernation and wake up in spring. The protagonist, a nineteen-year-old boy named Stefano, is forced to spend the hibernation period in the isolated house of his stepmother, his father's new partner.

When six-year-old Sophie is tragically orphaned guardianship is assigned to her estranged aunt Annabelle. The two move into a large, eerie, Victorian house where Sophie unearths a locked wooden box with a strange symbol drawn on it. Desperate to connect with her niece Annabelle pries the lock open revealing a beautiful music box. Each time the music box is wound and replayed it's surprisingly chilling melody plays slightly longer, captivating Sophie even more. When the music box begins affecting Sophie's behavior and health Annabelle seeks the aid of a child psychologist and clairvoyant who soon discover the music box is possessed by an evil spirit who seeks to haunt Sophie and destroy Annabelle. As the haunting intensifies time begins to run out and Annabelle finds herself racing against the music box's melody to defeat the spirit before the last note plays.

Barbara, a waitress in a hotel, has the vice to remove objects from guests rooms. Francesco, a student, finally meets a girl known on internet who hides a secret to him. Fausto, a chemist, invented an unusual way to export drugs with the help of another man. Susanna, a woman marked by a deep pain, plans a revenge against the man who wasted her life. The vicissitudes of four characters cross each other in the Japan Hotel in 24 hours, the presentation day of Mr. Teddy, a new prototype of a speaking teddy bear.