Lorelei Lee is a beautiful showgirl engaged to be married to the wealthy Gus Esmond, much to the disapproval of Gus' rich father, Esmond Sr., who thinks that Lorelei is just after his money. When Lorelei goes on a cruise accompanied only by her best friend, Dorothy Shaw, Esmond Sr. hires Ernie Malone, a private detective, to follow her and report any questionable behavior that would disqualify her from the marriage.

"The Hunchback" earns a scanty living as a tinker, traveling from house to house, but on account of his deformity, there is no one who cares for him. Although a great lover of children, they flee at his approach. Taking pity on a little girl whose doll has been broken, he spends all his earnings to replace her plaything, and in consequence, the people with whom he boards, order him out. Tired and despairing, he gets, unobserved, into a freight car, and is carried to a western mining town. There the wanderer finds friends in a miner and his little girl. An accident renders the little girl fatherless, and the hunchback brings the child to womanhood. As the years pass the cripple grows to care for his ward, but when he tells her of his love, he finds that it is not returned. The girl falls in love with a young prospector, and the jealous hunchback seeks to take his life, and then weakens in his resolve. Later the prospector is in deadly danger and the hunchback decides to let him die.

New York City tenement dwelling neighbors Blondie and Lottie are longtime best friends. When Lottie makes the cast of the Follies and moves up in the world, she arranges for Blondie, as well, to join the cast and gain the advantages. But the friendship goes awry when Lottie's sweetheart, wealthy Larry Belmont, falls for Blondie and she for him.

The story of a poor young woman, separated by prejudice from her husband and baby, is interwoven with tales of intolerance from throughout history.

D.W. Griffith short intercuts two different stories before mixing them together at the end. The film focuses on a telephone girl who leaves work for her lunch break at the same time as "The Lady" goes to a jewelry store to pick up some priceless jewels. When the telephone girl returns to work she gets a phone call from the house of "The Lady" as a robber has broken in and is trying to steal the jewels.

Laura Bell runs away from her country home to the city, where she becomes a clerk in a department store. Her brother, Frank, follows her to New York, but is unable to place her. He becomes interested in a settlement house and obtains a position in social service work. Mary Ashton, daughter of the proprietor of the store where Laura works, is shocked to find that her father pays his clerks starvation wages.

Before his niece and ward, Dosia Dale, comes of age, her uncle, who has spent her entire fortune, must think of a way to account for his actions. He proposes marriage, and when Dosia indignantly refuses him, he conspires with his evil friend, Dr. Protheroe, to do away with her. Declaring Dosia insane, the two men lock her up in the doctor's insane asylum, but she manages to drop a note from the window. Her plea for help is found by a reporter named Ford, who feigns insanity in order to gain admittance to the asylum. Dr. Protheroe becomes suspicious of Ford and locks him up with Dosia, whereupon Ford, knowing that his friend Cuthbert will notify the police if he and Dosia do not emerge safely by twelve, barricades the door and waits. In a furious battle with the police and the militia, Dosia's uncle and Dr. Protheroe are killed and the house set ablaze, but Ford and Dosia escape, leaping from the roof into a fire net below. All danger passed, Ford and Dosia become engaged.

Peggy Ainslee, the daughter of a wealthy broker, tires of the empty life of society, and determines on a mission of charity and uplift in the poor quarters of New York City

A happily married woman lets her catty friends talk her into divorce when her husband strays.

A healthy outdoors-type follows the girl he loves to a resort for wealthy hypochondriacs. In order to prove to her and the other patients that their "illnesses" are all in their minds, he hatches a scheme to take them on a boat ride, then get them stranded in the wilderness, where he can show them that they can live without their pills, doctors and "cures".