Florencia, the matriarch of the Filipinas family, is in poor health, and Yolanda, the eldest of the Filipinas children, finds herself in the unenviable position of keeping her bickering family from disintegration. As the tension rises, Yolanda seeks refuge in a local church. She is critically injured trying to break up a nasty fight between brothers Emman and Samuel, forcing her family to make a life-changing decision.

Sikil tells the story of two men and a woman who are involved in a bizarre love triangle. These three friends grew up in a small town south of Manila. Enzo is a young closet gay prostitute who's obsessed with his childhood friend who happens to be a call-boy and has a girlfriend. Other interesting characters are the bi-sexual pimp, a regular bathhouse customer, and a sampaguita vendor-pickpocket-shoplifter and caretaker of Adong's daughter.