Sister Italy is a heartfelt, hilarious, culinary escapade that follows the fortunes of two Italian-American sisters, Italia and Maria, who are rival cooks. They clash in an intriguing cooking competition.

Marion and Mingus both come from failed relationships but, by bringing their children together, they've managed to form a small yet happy family. Tensions in their household soon begin to spike when Marion's jovial father shows up on their doorstep with his randy daughter and her peculiar boyfriend in tow. As the motor-mouthed houseguests shatter every taboo imaginable, the happy couple begin to question their commitment.

Two gangsters seek revenge on the state jail worker who during their stay at a youth prison sexually abused them. A sensational court hearing takes place to charge him for the crimes.