A crew of five people and one sea dog leave Panama on March 7, 2020. One week into their passage, they receive news on the satellite email that Coronavirus has created a global pandemic.

When a teen from a wealthy family learns that she is adopted, Izzy hires a private investigator to find her birth parents. When a meeting is set up, Izzy hops on a bus to go meet her mom, but when the bus is taken over by hijackers, Izzy soon discovers her captors are using her as a ransom. Through it all, Izzy meets a variety of passengers, some who encourage her through faith in God and others who are conspiring against her.