After witnessing her parents’ murder as a child in Bogota, Cataleya Restrepo grows up to be a stone-cold assassin. She works for her uncle as a hitman by day, but her personal time is spent engaging in vigilante murders that she hopes will lead her to her ultimate target: the mobster responsible for her parents' death.

After accepting temporary work in a laboratory Cesar begins to notice strange events related to the treatment of a patient with the number 27, this disturbs him the extent of causing insomnia and hallucinations. Isela and Marcos, his coworkers attribute this to the Cesar fatigue, however the real reason for these views is more real and dangerous than they think.

In search of his sister, a renegade criminal seeks answers at a sordid hotel where he encounters a sinister guest and romances a mysterious waitress.