Rose was up all night dealing with two equally annoying pests—a horny boyfriend and a squeaking mouse that has somehow managed to climb into her bedroom ceiling. With her mother across the country attending a distant relative's funeral, Rose is home alone, and her boyfriend George is eager to capitalize on the opportunity. However, when Rose finds out that the mouse giving her a migraine scampered under her bed and ate a bag of her marijuana edibles, she and George must decide its fate.

Two heroin addicts are faced with a moral dilemma when their friend overdoses.