In LaBruce’s first short experimental super 8 film, a loose narrative is constructed out of a variety of film clips, some shot on location by the filmmaker, some found footage, and some shot off the television screen. A woman with long red hair (G.B. Jones) sits on a window sill and looks down with her binoculars at the street below. Meanwhile, Mary Tyler Moore escapes from an aggressive man and runs to the park. Boy/Girl is a documentation of a period of time when filmmaker LaBruce lived in a crummy, squat-like building at Queen and Parliament Streets in Toronto with the all-girl punk band, Fifth Column.

The ghost of "patient zero", who allegedly first brought AIDS to North America - materialises and tries to contact old friends. Meanwhile, the Victorian explorer Sir Richard Burton, who drank from the Fountain of Youth and now works as Chief Taxidermist at the Toronto Natural history Museum, is trying to organise an exhibition about the disease for the museum's "Hall of Contagion".