After stealing a fortune in unclaimed jewelry, ex-detective Barney Rickert arrives at a run-down dude ranch in Arizona to hide out. When owner Dewey Hoople refuses to sell to Rickert, he proceeds to win over the female inhabitants by seducing them one by one which leads to one refusing his advances and a dangerous game played out in which Rickert ruthlessly sets out to get what he wants.

The wild west was a lot wilder than most people know -- and A FIST FULL OF 44's shows it exactly as it was -- no punches pulled!