After five years in prison for a violent assault, everyone knows not to mess with Weaver – especially his step-son Rex. But when an innocent couple accidentally crossed paths with Weaver during an illegal hunting expedition, all hell breaks loose and Weaver's rage is unleashed again – and this time he's armed and dangerous. A tense cat-and-mouse chase through the wilderness ensures, leading to a deadly confrontation between Weaver and Rex and their human prey – a young woman with a strong survival instinct.

When their city is rocked by a series of brutal occult murders, veteran detective John Locke and his young partner Terri Keyes are forced to put aside their differences and follow the trail of evidence to a formerly abandoned asylum, where the new owner Dr Unnseine is conducting his own brand of Nazi-inspired "medical research" on the unwilling inmates. One such inmate, the sexy but deadly Annie Dyer, may hold the key to the murders - and to the doorway to Hell itself - if only Locke and Keyes can stay alive long enough to discover what it is.