Simone Segre, a renowned surgeon of Jewish origins, lives in a city in the north-east of Italy. A quiet life, an elegant apartment and no connection with his past. One day he finds himself assisting a man victim of a hit and run accident. But when he discovers a nazi tattoo on his chest, Simone abandons him to his destiny. Filled with guilt, he ends up tracing the man’s family: Marica, the eldest daughter; Marcello, a teenager plagued with racial hate; and little Paolo. The night will come when Marica knocks at Simone’s door and unknowingly asks for payback.

Robert McCall finds himself at home in Southern Italy but he discovers his friends are under the control of local crime bosses. As events turn deadly, McCall knows what he has to do: become his friends' protector by taking on the mafia.