Ana is 30 years old and lives with her parents. As her ex-husband takes their daughter and her nagging mother to the countryside, she prepares for a laidback evening with her friends. Soon she comes to realize she lost her cell phone which prevents her from receiving a much awaited call from her previous night's stand. Her friends, Iulia, Andrei and Marius, arrive and try to watch a movie. The screening is frequently interrupted by an increasingly annoying and rather absurd dialogue that takes place between the thief/finder of the cell phone and Ana.

After suffering terrible headaches and stomach cramps, Mr. Lăzărescu, a lonely 63 year-old man, calls for an ambulance, beginning one man’s hellish journey through Bucharest hospitals in search of proper medical care. As the night unfolds, his health starts to deteriorate fast.