Friends Mingo and Aníbal and their adventures in a luxurious hotel in Buenos Aires.

Upon turning 55, Pepe, a bank manager, feels bored with his life. He abandons his family, quits his job, takes a woman younger than him as a lover, and becomes associated with a moneylender.

When tragedy strikes, 16 year old, América Campos is sent to Argentina to live with her anti-American grandmother Lucía América. América struggles to find her place with a grandmother she has never known and to hold onto a friendship with Sergio, a neighbor twice her age.

Blood is a family portrait. A mother, her two children and the shadow of her husband who died 25 years ago under strange circumstances.