After a new cannery introduces scientifically augmented salmon to a seaside town in the Pacific Northwest, a species of mysterious, mutated sea creatures begin killing the men and raping the women.

Alice Tate, mother of two, with a marriage of 16 years, finds herself falling for a handsome sax player, Joe. Stricken with a backache, she consults herbalist Dr. Yang, who realizes that her problems are not related to her back, but in her mind and heart. Dr. Yang's magical herbs give Alice wondrous powers, taking her out of her well-established rut.

At the prompting of his diplomat friend, Alex, writer Ted Fletcher takes his wife, Laura, and daughter, Amy, on an extended working holiday. Alex finds a house for them in Kyoto, Japan, and the Fletchers move in, laughing off rumors that the place is haunted. But the ghost of 19th-century samurai Shigero turns out to be very real, and is intent on making the family re-enact an ancient murder-suicide.

A young woman is convicted on drug offenses and sent to a women's penitentiary run by a repressed and oppressive female warden. When the prison's sadistic doctor begins conducting illegal "therapeutic" experiments on the inmates, the ladies plot their revenge.