In Harlem in 1987, Claireece "Precious" Jones is a 16-year-old African American girl born into a life no one would want. She's pregnant for the second time by her absent father, and at home she must wait hand and foot on her mother, an angry woman who abuses her emotionally and physically. School is chaotic and Precious has reached the ninth grade with good marks and a secret – she can't read.

After becoming orphaned, a lonely girl moves in with her grandparents and tries to befriend a sick, bed-ridden boy next door, despite his mother’s strong objections. Her persistence leads to a friendship, but during secret visits, she uncovers dark secrets in the boy's home.

A young writer begins an affair with an older woman from France whose open marriage to a diplomat dictates that they can meet only between the hours of 5 p.m. to 7 p.m.