A look at the notorious Colombian Medellin cocaine cartel. Former coke addict has built a new life as contractor, but cannot shake off his past on drugs.

Rosario Tijeras has been abused by men all her life, initially by her stepfather. Years later, she works as a paid assassin, seducing men and killing them when they least expect it. She meets Emilio, a wealthy womanizer, and his best friend, Antonio, at a nightclub, and starts an affair with Emilio despite Antonio's growing feelings for her. But circumstances bring her closer to Antonio, until her past catches up with her in a devastating way.