In New France, in the year of grace 1642. Anguerant de Ganélon, witch hunter and hunter of monsters, leaves Europe accompanied by his valet and a priest in order to pursue the vampire who killed his wife.

Philippe, an opera composer in search of inspiration, is forced to take in Simone, his rebellious, eccentric niece whose best friend is a skunk. Despite their diametrically opposed personalities, Philippe and Simone quickly discover that they may need each other more than they first thought.