In 1990s Palermo, Pino Puglisi is a priest from the neglected Brancaccio neighborhood dedicated in helping kids to get off the streets and creating an embracing place of hope and solidarity in his church, which means trouble for the local Mafia. He continues his solitary fight until the bitter end.

Franco Califano, fallen and resurrected several times, begins his third life after the years of drugs and prison, of a youth lived to the last breath, appearing at Sanremo just to come in last in the rankings. But his third life as an artist has just begun, and it takes place during the sold-out concerts organized by his unconventional manager who, instead of choosing high-end venues, sets dates in dance halls and trattorias frequented by the people who love him. Around Franco, his lifelong friends, who have common names, far from show business, and who support and encourage him, look after him while the blows of age and a wild life begin to be felt, while his legend, destined to last, continues to grow.

Valerio, a policeman and kickboxing champion, is about to become a father. His partner Valentina, with whom he is deeply in love, is expecting a child and the young couple's life seems to be going well. Valentina, however, cultivates the desire to become an actress and often finds herself meeting shady individuals such as the film producer and crime boss Sergio Bruschi. Valentina's sudden death following the unknowing intake of the so-called date rape drug during a meeting with Bruschi pushes Valerio to devote himself to an insane and terrible revenge.

Ciccio D.O.P., undisputed lord of the mozzarella kingdom, sees his dairy empire imperiled when enigmatic Chinese producers unleash a half-priced, top-quality mozzarella on Italian shelves, igniting a brutal market war. As he scrambles to defend his realm, his daughter Sofia, the crooner Angelo Tatangelo, former flame Autilia “Jazz-Mood,” and ex-water-polo champ Dudo are swept into a high-stakes struggle that tests loyalties, reignites old passions, and reveals the true cost of domination.

A promising law student from a good family is driven by a cool cardsharper into a downward spiral of criminality, discovering a part of himself he had never known.

The Camorra is on its knees and the credit goes to Gomorroide, an unexpectedly successful television series that mocks the ruthless criminal organization. Thanks to the TV series, people are less afraid of bosses and the underworld and have found the courage to rebel against abuses. The three main actors are real stars but one day the television station receives an envelope with three bullets addressed to them. However, no one takes the intimidation seriously, at least until a series of events and misunderstandings force the trio to enter a protection program that will toss them up and down Italy. Unjustly accused, the Camorra will not stand by and watch.

A Police Inspector hunts him down: Nicola, supported by the boss Cantalamessa, and protected by some criminal families, moves away from Naples, leaves his wife and children and becomes one of the many fugitives forced between hiding places and constant movements.

Rome, 1965. The entire city awaits the inauguration of the Piper. While the journalist Roberto Benetti falls in love with Sabrina May, the kept woman of a politician, thus giving up a scoop, the young Mario, leader of the band "I demoni", meets Milena, who has fled from Venice to sing. A fortuitous event will offer the two young people the opportunity to perform in the legendary club.