Zona Zamfirova is set in the eastern Serbian city of Niš in the 19th century. The plot follows the story of Zona Zamfirova, a local rich man's daughter, and the vicissitudes of her affair with Mane, an ordinary goldsmith. As it was undesirable for the daughter of a rich man to marry a craftsman, the two are at first divided, with the possibility of Zona marrying Manulać, who came from a wealthy family. Everything is, however, changed as Mane organizes a successful conspiracy to keep Zona for himself.

First Serbian film shot in Kosovo after its separation, exploring the relations between Serbs and Albanians is inspired by true events and depicted through the fate of two tragic heroes and their families. The film was created from the personal experience of producer and screenwriter Predrag Raonić, observing the reality of journalistic work.