Between 1952 and 1953, the young doctor Ernesto Guevara de la Serna traveled through Latin America. This film is based on his diaries, the correspondence with his family and friends, and the testimonies of those who knew him and accompanied him on this journey. That trip through the open veins of Latin America led him to become the Che.

The life of Ernesto Guevara retold in testimonies from those who knew him personally.

In 1952, Ernesto Guevara, then a medical student aged 23, and his friend Alberto Granado, a biologist of 29, began a long journey through the South American continent. During their tour, which began with an old motorcycle to continue after hitchhiking, they witnessed the harsh living conditions of the population of the countries they travelled. Guevara, soon to be known as Che, recorded his impressions in a diary. In 2002, the Brazilian director Walter Salles began shooting a film about that odyssey, "The Motorcycle Diaries". This documentary follows the making of that movie in detail, incorporating interviews with various participants.

Twenty years after Che’s death, in 1987, Pierre Richard and his journalist friend Jean Cormier set out to follow in his footsteps in Cuba. Through a series of encounters, their journey brings the revolutionary guerrilla back to life through numerous firsthand accounts.