Cesare Proietti is the esteemed manager of the Relais Colombo, a luxury hotel in Milan. When a group of new Chinese business partners want to revolutionize everything, the hotel owner's daughter, Luciana, decides to fire Cesare. When Cesare discovers Luciana is looking for a caregiver who can look after her father, he decides to dress up as a charming woman to apply for the role.

Fabrizio, a poor thief from the Roman suburbs, finally has in his hands the man who ruined his life: James Bond.