Two seemingly homeless men waiting for someone or something named Godot. Vladimir and Estragon wait near a tree on a barren stretch of road, inhabiting a drama spun from their own consciousness.

Hamm is blind and unable to stand; Clov, his servant, is unable to sit; Nagg and Nell are his father and mother, who are legless and live in dustbins. Together they live in a room with two windows, but there may be nothing at all outside.