A troubled woman seeks out the child she gave up for adoption; a gay motel owner takes in a handsome drifter; and the wife of a preacher frets that a gay couple has moved in across the street. All of their lives will intersect as Loggerheads subtly draws out their secret losses and desires.

When a Jewish songstress is plucked from the stage and sent to Auschwitz, she and other musicians find themselves assigned to a terrible task—using their talents to soothe fellow prisoners who are sentenced to die in the gas chambers.

When the popular, restless Landon Carter is forced to participate in the school drama production, he falls in love with Jamie Sullivan, the daughter of the town's minister. Jamie has a "to-do" list for her life, as well as a very big secret she must keep from Landon.

On the eve of his campaign launch for a seat in the US Senate, a small town District Attorney receives word that the governor has exonerated a death row inmate whom the DA prosecuted five years earlier for the murder of a local police officer. In the wake of the ex-inmate's release and through the prism of the media frenzy, what unfolds is a public vetting of the DA's record. When hard evidence of actual impropriety finds its way into his possession, the exonerated man seeks out the DA for answers.

A bereaved man takes a job at a health care center, where he befriends an elderly and embittered woman - and as time passes, he becomes obsessed with reuniting her with her long-lost true love.