Official Shogunate executioner Ogami Itto has been framed for disloyalty to the Shogunate by the Yagyu clan, against whom he now is waging a one-man war, along with his infant son, Daigoro.

Ogami Itto is hired to kill a tattooed female assassin and battles Retsudo, head of the Yagyu clan, and his son Gunbei.

With most of his family already dead at Ogami Itto's hands, Retsudo launches one final plot to destroy him, and when that fails, unleashes the fury of every remaining member of the Yagyu clan.

Ogami Itto is challenged by a quintet of warriors, each armed with one fifth of Ogami's assassin fee and one fifth of the information he needs to complete his assignment.

A Shogun who grew paranoid as he became senile sent his ninjas to kill his samurai. They failed but did kill the samurai’s wife. The samurai swore to avenge the death of his wife and roams the countryside with his toddler son in search of vengeance.

Gokudo Shimamura comes to blows with the Delinquent Boss who rolls into town with his motorcycle gang.

Ogami Itto battles a group of female ninja in the employ of the Yagyu clan and must eliminate a traitor who plans to sell his clan's secrets to the Shogunate.

Ogami Itto volunteers to be tortured by Yakuza in order to save a prostitute and is hired by their leader to kill an evil chamberlain.