The Yamada family lives in Tokyo's Higashi Edogawa Ward. Noboru, the second son and high school student, dreams of becoming a professional baseball player. One day, he hears about a scout from a pro team! However, it turns out that it's not a pro baseball player, but a scout to become a professional wrestler! Ine, the housewife of the Yamada family and landlady of the Yamada-so apartment building they run, has recently gained weight. To lose weight, she joins a nearby tennis club, but there she runs into her son, Noboru, who is trying to join the club in search of girls!

In 1984 the Japanese government approved gene recombination experiments. Baggy is Tezuka’s response. A cute kitten escapes a lab, and is befriended by lonely child Ryosuke. Years later, he joins her in a quest that’s part spaghetti Western, part contemporary adventure.

Marielle is a young girl currently living in a remote house deep in the mountains between Switzerland and France to recover her health. The story is told through the memories of her adventures with Memoru, a tiny alien girl who lives on a nearby island. Her people are gnome-like beings who are stuck on Earth after their spaceship crashed here.